Entresto Generic Is Here: 2026 Cost & How to Save

If you've been paying $600 or more a month for Entresto, here's news your wallet has been waiting for: the Entresto generic is finally on U.S. pharmacy shelves. Sacubitril/valsartan tablets launched in July 2025, and by 2026 supply is steady across the country.

The catch? Plenty of people are still paying brand-name prices — sometimes because their pharmacy never mentioned the switch, sometimes because even the generic's retail price is higher than it should be. Here's what generic Entresto actually costs in 2026, and how to pay far less than the sticker price.

Is there a generic for Entresto?

Yes. The FDA approved the first generic versions of Entresto back in May 2024, but patent litigation kept them off pharmacy shelves for over a year. That ended in July 2025, when a federal judge ruled Novartis couldn't block the generic launch — and MSN Pharmaceuticals shipped the first sacubitril/valsartan tablets within days.

Since then, several more manufacturers, including Lupin, have entered the market. That competition matters: the more companies making a generic, the faster prices fall and the less likely you'll run into supply gaps. Pharmacists report solid availability across all three tablet strengths.

The generic covers every dose of Entresto tablets: 24/26 mg, 49/51 mg, and 97/103 mg, taken twice daily.

What is sacubitril/valsartan?

Sacubitril/valsartan is the generic name for Entresto — the same two active ingredients, in the same strengths, working the same way.

It's the only drug in its class, called angiotensin receptor-neprilysin inhibitors (ARNIs). Sacubitril blocks a protein called neprilysin, which helps your body clear excess fluid, improves blood flow, and protects the heart from further damage. Valsartan — also sold on its own as the blood pressure drug Diovan — is an angiotensin II receptor blocker (ARB) that relaxes blood vessels and takes strain off the heart.

Together, they've become a first-choice treatment for chronic heart failure. In clinical trials, sacubitril/valsartan lowered the risk of heart failure hospitalization within 30 days of starting treatment, and modeling studies suggest it may extend life expectancy by about 1.5 years compared with enalapril, an older heart failure medication.

How much does generic Entresto cost in 2026?

Here's where the numbers get interesting — and where paying attention can save you thousands per year.

A few things stand out in that table.

First, the generic's retail price is still high. If you walk into a pharmacy and pay cash without comparing prices, $450+ a month for a generic is a real possibility. Retail generic pricing often stays inflated for the first year or two after launch.

Second, the gap between retail and discounted cash prices is enormous. Through CanAmerica Plus, sacubitril/valsartan starts at $119.99 for 140 tablets — a 70-day supply at the standard twice-daily dose. That works out to about $52 a month, at any strength. Compared with brand-name retail, that's a savings of more than 90%.

What about Medicare?

Entresto was one of the first ten drugs selected for Medicare price negotiation under the Inflation Reduction Act. The negotiated price took effect January 1, 2026: $295 for a 30-day supply of brand-name Entresto, down roughly 53% from its previous list price of about $628.

That's meaningful if you're on Medicare Part D and staying on the brand. But note two things. Your actual out-of-pocket cost depends on your plan's deductible and copay tier, and the $2,100 annual Part D out-of-pocket cap for 2026 also limits your total exposure. And for many people, a discounted cash price on the generic — around $50 a month — still beats their Part D cost-sharing on the brand. It's worth running both numbers before you assume insurance is the cheaper route.

Is generic Entresto as good as the brand?

The FDA requires generic drugs to contain the same active ingredients, in the same strengths, with the same safety and effectiveness as the brand. Generic sacubitril/valsartan met that bar before it could be approved.

The differences you might notice are cosmetic. The tablets may be a different shape or color depending on the manufacturer, and the label will read "sacubitril/valsartan" instead of Entresto. A large analysis of insurance claims covering more than 2 million matched patient pairs found generics delivered comparable clinical outcomes to their brand-name counterparts.

Side effects are the same as brand-name Entresto: low blood pressure, dizziness, cough, elevated potassium, and changes in kidney function are the most common. The same boxed warning applies too — sacubitril/valsartan can seriously harm an unborn baby and should never be taken during pregnancy. If you switch and anything feels off, tell your prescriber. But for the vast majority of people, the switch is uneventful — except at the register.

One more safety note that applies to brand and generic alike: don't stop taking it on your own. Stopping heart failure medication abruptly can worsen symptoms and raise the risk of hospitalization. If cost is pushing you toward skipping doses, that's exactly the moment to look at cheaper sources — not to stretch your supply.

Is there a generic for Entresto Sprinkle?

Not yet. Entresto Sprinkle — the capsule version that can be opened and mixed with soft food for people who have trouble swallowing pills — is still brand-only.

If swallowing tablets is the issue, ask your pharmacist about options. In some cases, pharmacists can prepare an oral liquid from the generic tablets, which keeps you on the lower-cost version.

How to switch and save

You don't need to do much — but a five-minute conversation can save you real money.

Ask your pharmacist whether you're currently getting brand or generic. If your fill still says Entresto, ask for sacubitril/valsartan by name. Then compare your insurance copay against discounted cash prices — insurance isn't automatically cheaper, especially if you're in your deductible phase or your plan puts the drug on a high tier.

If you're comparing cash-pay options, check prices at more than one source. Retail pharmacy cash prices for this generic vary by hundreds of dollars a month. Through the CanAmerica Plus network, sacubitril/valsartan runs about $52 a month at every strength, with pricing you can see up front before you commit.

The same playbook applies to other recently launched generics — if you're on a blood thinner, we've covered the Xarelto generic and the timeline for generic Eliquis as well. And if you want the full picture on brand-name pricing, see our breakdown of Entresto costs in 2026.

The bottom line

Generic Entresto is real, FDA approved, and widely stocked in 2026 — and it works exactly like the brand. The difference is price: brand retail runs $750+ a month, generic retail around $450–$530, and smart cash-pay routes bring it down near $50. Check what you're actually being dispensed, compare your insurance price against cash options, and talk to your doctor before making any change to how you take it.

Frequently asked questions

How much is generic Entresto without insurance?

Average retail prices run $450–$530 for 60 tablets, but discounted cash prices are far lower. Through CanAmerica Plus, sacubitril/valsartan starts at $119.99 for 140 tablets — about $52 a month at the standard twice-daily dose.

Who makes generic Entresto?

MSN Pharmaceuticals launched the first U.S. generic in July 2025, and other manufacturers including Lupin have since entered the market. Your pharmacy may stock any of them; the active ingredients are identical.

Is generic Entresto as effective as brand-name Entresto?

Yes. The FDA requires generics to match the brand's active ingredients, strength, safety, and effectiveness. Large real-world studies of brand-to-generic switches show comparable clinical outcomes.

Can I still get brand-name Entresto?

Yes. Novartis continues to sell brand-name Entresto, and Medicare's negotiated price of $295 per 30-day supply took effect in January 2026. Entresto Sprinkle capsules remain brand-only.

This article is for informational purposes only and does not constitute medical advice. Always consult with a qualified healthcare provider for diagnosis and treatment. Pricing information is current as of the publication date but may change. Verify pricing directly before making purchasing decisions.