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Bosentan

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Bosentan is a dual endothelin receptor antagonist used primarily in the treatment of pulmonary arterial hypertension (PAH). It works by blocking the effects of endothelin-1, a substance in the walls of blood vessels that causes them to narrow. By blocking the action of endothelin-1, bosentan helps decrease blood pressure in the lungs, improve symptoms, and increase the ability to exercise.

How is this medication used?

Bosentan is taken orally, usually twice a day in the morning and evening, with or without food. Dosage may vary based on individual health conditions or treatment response. It is important to take bosentan at the same times every day to maintain an even level of the medication in the blood.

What are the possible side effects?

Common side effects of bosentan include headache, respiratory tract infection, flushing, low blood pressure, sinusitis, liver function abnormalities, and edema. Liver function should be monitored regularly while taking bosentan due to the risk of liver damage.

What are the potential interactions?

Bosentan can interact with other medications, such as cyclosporine and glyburide, leading to potentially dangerous effects. It may also decrease the effectiveness of hormonal contraceptives, so alternative or additional contraceptive methods should be used. The medication's effectiveness can be affected by certain drugs that induce or inhibit CYP450 enzymes, particularly CYP2C9 and CYP3A4.

Disclaimer: The information provided on this website is for informational purposes only and is not intended as medical advice. Always consult with your healthcare provider for medical advice, diagnosis, or treatment. Images are for representation purposes only and actual packing may differ by brand and/or manufacturer.